Deadpool 2 is the 2018 sequel to the 2016 Marvel feature film adaptation of the irreverent anti-hero character. Ryan Reynolds returns as Wade Wilson, aka "Deadpool", who forms a special team to stop an assassin who has arrived from the future to eliminate a teenage mutant. The film was helmed by David Leitch, who co-directed the original John Wick.
An alternate PG-13 cut of the film, titled Once Upon a Deadpool, was released into theaters on December 12th, 2018. This version was framed as the titular character telling the story of Deadpool 2 to Fred Savage, parodying The Princess Bride in which a young Savage was told a bedtime story by Peter Falk who avoided "the scary parts that were a bit too adult for the youngster."
The following weapons were used in the film Deadpool 2:
IWI Desert Eagle Mark XIX
Deadpool (Ryan Reynolds) continues to carry twin IWI Desert Eagle Mark XIX pistols as his primary firearms. Cable takes one of Deadpool's Desert Eagles and tries to shoot him during the convoy scene. The Desert Eagles in this movie are a new set, not the same guns from the previous film: This time, the Eagles have ported barrels and the bore is engraved with "SMILE Wait 4 Flash", though this engraving is not visible in the finished film.
Arsenal Firearms AF2011-A1
Beretta 92FS (Two-tone Gold)
The Beretta 92FS is carried by police officers.
Beretta Px4 Storm
A few of the DMC guards are armed with the Beretta Px4 Storm pistol. Deadpool uses this gun to make the driver shoot himself after his hand was shot by the said gun.
Colt Model 1908 Vest Pocket
"Blind Al" (Leslie Uggams) is seen pulling what appears to be the Colt Model 1908 Vest Pocket with pearl grips that she carried in an ankle holster during the events of the original film. Humorously, Wade threw the pistol away into a large rubble pile after firing it during the climax at the shipyards, so it's unlikely that Blind Al ever could have gotten it back. Either Blind Al owns two or she bought a new pistol.
A gangster pulls a gold-plated Colt M1911A1 when confronted by Deadpool.
Taurus PT92 (nickel)
What appears to be nickel Taurus PT92 pistols are pulled by gangsters at the film's beginning.
A TiSAS Zigana is used by a gangster before being taken down by Deadpool.
Walther PPQ Q5 Match
Heckler & Koch MP5A3
A gangster briefly uses what appears to be a two-tone gold Heckler & Koch MP5A3 when Deadpool takes down a drug factory.
A Vickers Mk1 is seen behind Deadpool and Weasel.
A Lewis Gun is seen on a table.
DMC guards are armed with Kel-Tec KSG shotguns.
A Mossberg 500 shotgun with a field barrel is one of the shotguns used by the attendants of the Essex School. Deadpool briefly uses this shotgun when his Desert Eagles run dry and obtains it after killing one of the Essex attendants with a brick.
Cable uses what appears to be a standalone FN EGLM grenade launcher during his attack at the Ice Box.
Cable (Josh Brolin) carries a highly customized rifle that has been put together with parts from a KRISS Vector, AR-15, a Barrett M82, an M203 Grenade Launcher, and an M1928 Thompson. It is called the "BFG" in promotional media, which presumably stands for "Big F**king Gun" (not to be confused with the real BFG). In the Super Duper Cut, he robs a store and steals an amplifier from a guitar. This amplifier is used as a fire control device, as it changes how the weapon operates depending on what number is it set to. It goes up to 11, a reference to Spinal Tap. Notably the weapon is fired at an extremely high firerate (and is also never reloaded), presumably due to using a Vector as a base, and the M203 is actually some sort of powerful airblast cannon instead of a grenade launcher.
When Deadpool is interviewing candidates for X-Force, several weapons are seen in the backroom.