The following weapons were used in the film Drugstore Cowboy:
Colt Detective Special
Bob Hughes (Matt Dillon) carries a Colt Detective Special. In one shot, Bob puts the Detective Special down and an extreme close-up shows a Smith & Wesson revolver. David's accomplice (Ray Monge) carries a Detective Special when he and David try to rob Bob of drugs in the finale.
Colt Detective Special - .38 Special
Bob puts his Detective Special in David's face upon answering the door.
Bob handles his Detective Special as he negotiates with David.
Bob threatens Nadine with his snubnose during the negotiation with David.
David's accomplice intimidates Bob with his Detective Special.
Rick (James LeGros) carries a M1911A1 when David comes to the door.
Rick points his 1911 at the door as Bob greets David with his Detective Special.
Smith & Wesson Model 36
Gentry (James Remar) carries a Smith & Wesson Model 36 when he leads the policemen on the drug bust on Bob and Diane's house. David (Max Perlich) and his accomplice also each carry Smith & Wesson Model 36 revolvers when they go to rob Bob's apartment for drugs in the finale.
Smith and Wesson Model 36 - .38 Special
When Bob puts his Detective Special down on the table, it turns into a Model 36 for an extreme close-up.
Gentry points his Model 36 at Bob.
Smith & Wesson Model 36 with 3" Barrel and square butt - .38 Special
David and his friend await Bob.
David points his snubnose at Bob.
A flintlock pistol hangs on the wall in Bob's house.
Rick walks past a flintlock as he leaves Bob's house.
Mossberg 500 AT
Bob's neighbor (Ted D'Arms) carries a Mossberg 500 AT shotgun with long barrel, when Bob warns him about the "intruders".
Mossberg 500AT Shotgun - 12 gauge.
The neighbor spots men walking outside his window.
The neighbor fires at the undercover police on ladders outside his window.