Based on the anime film Blood: The Last Vampire, Blood+ is a 50 episode anime television series that tells the story of Saya Otonashi, a teenage amnesiac who must regain her memory if she's to destroy the Chiropterans, a vicious horde of blood drinking shape-shifters that have plagued Japan for centuries.
The following weapons appear in the anime television series Blood+:
Saya's father George owns a M1911A1 which is seen drawn during flashbacks scenes with him and Saya. George mentions that he is ex-US military, so it's likely he kept this weapon after leaving the military. Kai later takes this weapon to chase down the Chiropteran that attacked and wounded George. He fires the whole magazine at the Chiropteran, but the rounds have little effect as the Chiropteran regenerates its wounds. David takes this weapon away from Kai, but gives it back to him later in the series so he can protect himself. Kai has little knowledge of firearms; But after the destruction of the Red Shield Ship, he constantly practiced his aim with the M1911 until he becomes proficient with it. At one point he even loads special explosive rounds in his gun to suppress Chiropterans.
Smith & Wesson Model 500
David carries a massive Smith & Wesson Model 500 as his primary arm in most parts of the show. A handgun this size may seem unconventional for an agent to carry, but since Chiropterans cannot be killed by conventional means, Red Shield agents have to rely on the knock down power of their guns to keep them at bay.
Tokarev TT-33 Pistol
When reporter Akihiro tries to sneak in into the private school in Vietnam, he is caught and held at gunpoint with a Tokarev TT-33 pistol.
Red Shield agent Rogers draws a Browning Hi-Power when a Chiropteran jumps on McCoy.
SIG Pro SP2022
Dr. Collins uses a SIG Pro SP2022 to try to kill Julia. Although is hard to tell the model of the gun it seems to be a SIG Pro SP2022
During the final fight at the Metropolitan Opera House (Episodes 48 to 49), US government agents use Beretta 92FS to fight Chiropterans. Apparently some of them are converted to full auto. Surprisingly, a semi auto Beretta 92FS seems to be capable of containing a single Chiropteran with no problem.
During flashbacks of Saya's past in Vietnam, US soldiers are carrying M16A1 rifles. The soldiers fire these weapons at Saya when she is going berserk, but the rounds do little to slow her down.
Colt Model 933
After Saya's first Chiropteran encounter, a U.S. Special Forces team armed with Colt Model 933 carbines, secures the area. Later, Lewis is seen wielding a Model 933 when Kai approaches him on his motorcycle. In both instances they are fitted with Surefire M900 weaponlight foregrips and EOTech red dot sights.
When David is selecting his weapons before going to rescue George, a rifle that resembles a Barrett M82 is seen in the gun case.
An AK-47 is seen briefly when Saya's school visits the Vietnam War museum in Episode 10.
An M1 Carbine is seen briefly when Saya's school visits the Vietnam War museum in Episode 10.
Winchester Model 70
A Winchester Model 70 rifle is seen in the Vietnam War museum.
During a flashback scene in Episode 6, a picture is shown of U.S. Soldiers during the Gulf War carrying M16A2 Rifles.
Heckler & Koch MP7A1
Cinq Fleche security guards carry Heckler & Koch MP7A1.
When Saya, Hagi and David go to rescue George, David equips himself with a Franchi SPAS-12 with no stock and loaded with slug rounds. Lewis mentions that this weapon is not enough to kill a Chiropteran, but David comments that it's all he needs because Saya is the ultimate weapon against Chiropterans. In Episode 12, Red Shield agents McCoy, Spencer, and Rogers all carry SPAS-12s when the group assaults the Cinq Fleche facility in Vietnam. Lewis also uses a SPAS-12s on various occasions throughout the series.
M60 machine gun
A US soldier is seen with a M60 machine gun in a picture at the Vietnam War Museum in Episode 10.
Browning M2HB Heavy Machine Gun
A Browning M2HB heavy machine gun is seen briefly in Episode 12.
Red Shield Agent Clara carries a M249 SAW in Episode 12, often seen firing it from the hip in an unusual fashion; using the carrying handle instead of the handguard.
M26 hand grenade
An American M26 hand grenade is seen briefly when Saya's school visits the Vietnam War museum in Episode 10.
M18 smoke grenade
An American M18 smoke grenade is seen briefly when Saya's school visits the Vietnam War museum in Episode 10.
M16A2/M203 Grenade Launcher
During a flashback scene in Episode 6, a picture is shown of a U.S. Soldier carrying an M16A2 rifle fitted with an M203 grenade launcher.
During a flashback scene in Episode 6, a picture is shown of a U.S. soldier in the Gulf War carrying an M136 AT4.
M79 grenade launcher
M41 Walker bulldog tank
South Vietnamese Army (ARVN) M41 Walker bulldog tank is seen briefly when Saya's school visits the Vietnam War museum in Episode 10.
M48 Patton tank
A M48 Patton tank is seen briefly when Saya's school visits the Vietnam War museum in Episode 10.
A WW2 Soviet made M1938 122mm Howitzer (left of Patton tank) is seen briefly when Saya's school visits the Vietnam War museum in Episode 10.