FN Five-seveN USG (U.S. Government) model - FN 5.7x28mm
The Framework version of Melinda May takes aim at Vijay inside a HYDRA interrogation room in "What If..." (S4E16).
The Framework version of Grant Ward grips his sidearm after confronting Skye and Jemma.
Jemma confronts Dr. Radcliffe in "Identity and Change".
"Not cool, bro". Coulson glares at Radcliffe when he confronts him.
The Framework version of Leo Fitz aka the Doctor aims a USG at Agnes.
Radcliffe turns the tables on the Framework version of Fitz in "Farewell, Cruel World!" (S4E20).
A Glock 17 with a stainless steel slide is used by Coulson after he and the others rescue Yo-Yo from Watchdogs near the end of "Uprising" (S4E03). Some of the armed men helping Morrow are armed with this in "The Laws of Inferno Dynamics" (S4E08). Fitz uses it at the end of "Wake Up" (S4E11) to open fire at Radcliffe at the holding cell in the Playground. May uses it as her official sidearm before SHIELD changed sidearm. Most law enforcement agencies use factory black Glock 17 pistols as their sidearm.
Glock 17 (3rd Generation) with stainless steel slide - 9x19mm
Coulson with the Glock 17 in "Uprising" (S4E03).
An armed man aims his sidearm at Coulson in "The Laws of Inferno Dynamics" (S4E08).
Glock 17 - 9x19mm
USCP officer make an arrest after a break-in in Sen. Nadeer's office in "Wake Up" (S4E11).
Fitz fires the pistol at Radcliffe.
May clears a room in "The Man Behind the Shield" (S4E14).
Vijay opens fire at the ceiling in "Broken Promises" (S4E09).
Springfield Armory XD
A Springfield Armory XD with a stainless steel slide is used in "Hot Potato Soup" (S4E12) by Shockley. It is likely the same prop used by Vanchat in Season 1.
Springfield Armory XD Service with two-tone finish - .40 S&W
Shockley aims the pistol at Billy (Patton Oswalt)'s temple in "Hot Potato Soup" (S4E12).
A Tokarev TT-33 is used by a Russian Watchdog terrorist in "Hot Potato Soup" (S4E12).
Tokarev TT-30, first version of Tokarev pistol - 7.62x25mm Tokarev.
The Watchdog terrorist fires his TT-33 at Sam in "Hot Potato Soup" (S4E12).
The FN P90 is used by Framework HYDRA assaulters as their main submachine gun.
FN P90 - FN 5.7x28mm
Framework HYDRA assaulters accompany May in "Identity and Change" (S4E17).
Skye with a stolen P90.
May infiltrates a HYDRA compound in "No Regrets" (S4E18).
Heckler & Koch MP5A3
Heckler & Koch MP5A3s with railed handguards are used in "The Patriot" (S4E10) by some mercenaries. Simmons uses once when the Playground goes on lockdown in "Self Control" (S4E15). Coulson uses it when he infiltrates a HYDRA compound in "No Regrets" (S41E18).
Heckler & Koch MP5A3 - 9x19mm
A mercenary takes aim at Director Mace in "The Patriot" (S4E10).
Simmons aims the MP5A3 at the human SHIELD agents in "Self Control" (S4E15).
In this far shot, you can see the MP5A3 configuration with railed handguard.
Coulson with the railed MP5A3 in "No Regrets" (S4E18).
Masked Watchdogs ambush Daisy, Simmons and James in "Let Me Stand Next to Your Fire" (S3E04).
A Colt M4A1 is used by a Watchdogs terrorist during an attack in Miami in the middle of "Uprising" (S4E03), being used as one of their weapons alongside the G36C. SHIELD assaulters use them as one of their main weapons. USAF Airmen use them in the raid on the Playground in "The Return" (S4E21). A black ops element snatches Coulson's team at the end of "World's End" (S4E22).
Colt M4A1 with carrying handle removed - 5.56x45mm
The Watchdogs terrorist with the M4A1 with no carry handle in "Uprising" (S4E03).
Colt M4A1 with 4 position collapsible stock, RIS foregrip, folding rear sight, and ACOG scope - 5.56x45mm
The discarded assault rifle on the ground at the end of "Lockup" (S4E05).
SHIELD assaulters with May and Mack at the end of "The Good Samaritan" (S4E06).
A Watchdog with a EOTech-equipped M4A1 in "Broken Promises" (S4E09).
Yo-Yo takes cover when a hijacked SHIELD gunship opens fire.
The Framework version of Mack knocks out a Framework HYDRA assaulter in "All the Madame's Men" (S4E19).
The Framework version of Tripp leads a SHIELD element to infiltrate a suspected HYDRA facility.
SHIELD fighters prepares to breach a room.
USAF airmen breach the Playground in "The Return" (S4E21).
A black ops assaulter secures Coulson's team at the end of "World's End" (S4E22).